R.E. Bell Lecture

Revisiting and Repurposing the Double Helix

Taekjip Ha

Thomas C. Jenkins Department of Biophysics
Johns Hopkins University

DNA is an iconic molecule that forms a double helical structure, providing the basis for genetic inheritance, and its physical properties have been studied for decades. In this talk, I will present evidence that sequence dependent physical properties of DNA such as flexibility and self-association may be important for biological functions. In addition, I will present a new application of DNA where mechanical modulations of cell behavior can be studied at the single molecule level using rupturable DNA tethers.