Research Areas

Nanofluidics

Polymer physics of DNA

Biophysics and biotechnology

Nanoscale fabrication techniques

Recent Publications

Flossing DNA in a Dual Nanopore Device
Xu Liu, Philip Zimny, Yuning Zhang, Ankit Rana, Roland Nagel, Walter Reisner and William B. Dunbar
Small, DOI:10.1002/smll.201905379
Technique improves solid-state nanopores
Stacy W. Kish
AIP Scilight, DOI:10.1063/10.0000467
An apparatus based on an atomic force microscope for implementing tip-controlled local breakdown
T. St-Denis, K. Yazda, X. Capaldi, J. Bustamante, M. Safari, Y. Miyahara, Y. Zhang, P. H. Grutter, and W. Reisner
Review of Scientific Instruments, DOI:10.1063/1.5129665
Controlling DNA Tug‐of‐War in a Dual Nanopore Device
Xu Liu, Yuning Zhang, Roland Nagel, Walter Reisner and William B. Dunbar
Small, DOI:10.1002/smll.201901704
From 2D to 3D: Graphene molding for transparent and flexible probes
Martin Lee, Thai-An Vuong, Eric Whiteway, Xavier Capaldi, Yuning Zhang, Walter Reisner, Carlos S.Ruiz-Vargas and Michael Hilke
Appl. Phys. Lett. 114, 043301 (2019) DOI:10.1063/1.5075618
Nanopore Formation via Tip‐Controlled Local Breakdown Using an Atomic Force Microscope
Yuning Zhang, Yoichi Miyahara, Nassim Derriche, Wayne Yang, Khadija Yazda, Xavier Capaldi, Zezhou Liu, Peter Grutter, Walter Reisner
Small Method, DOI:10.1002/smtd.201970018

Controlling DNA Tug-of-War in a Dual Nanopore Device
Xu Liu, Yuning Zhang, Roland Nagel, Walter Reisner, William B. Dunbar,.
arXiv:1811.11105
Single Molecule DNA Resensing Using a Two‐Pore Device
Yuning Zhang, Xu Liu, Yanan Zhao, Jen-Kan Yu, Walter Reisner and William B.Dunbar,.
Small, 2018, DOI:10.1002/smll.201801890

Probing the organization and dynamics of two DNA chains trapped in a nanofluidic cavity
Xavier Capaldi, Zezhou Liu, Yuning Zhang, Lili Zeng, Rodrigo Reyes-Lamothe and Walter Reisner,.
Soft Matter, 2018, DOI:10.1039/c8sm01444b

Transverse dielectrophoretic-based DNA nanoscale confinement
Sara Mahshid, Jia Lu, Abrar A.Abidi, Robert Sladek, Walter W.Reisner &Mohammed Jalal Ahamed,.
Scientific Reports 8,Article number: 5981(2018)

A Nanofluidic Knot Factory based on Compression of Single DNA in Nanochannels
Susan Amin, Ahmed Khorshid, Lili Zeng, Philip Zimny, Walter Reisner,.
Nature Communications 9, Article number:1506(2018)

Hydrogel Droplet Single-Cell Processing: DNA Purification, Handling, Release, and On-Chip Linearization
Philip Zimny, David Juncker and Walter Reisner.
Biomicrofluidics 12, 024107(2018);

Compression of Nanoslit Confined Polymer Solutions
Yue Qui, Lili Zeng, Ahmed Khorshid, Reghan Hill and Walter Reisner.
Macromolecules 2018, 51, 2, 617-625

Waves of DNA: Propagating excitations in extended nanoconfined polymers
Alexander R Klotz, Hendrick W de Haan, Walter W Reisner.
Physical Review E

Dynamics of DNA Squeezed Inside a Nanochannel via a Sliding Gasket
Aiqun Huang, Walter Reisner, Aniket Bhattacharya.
Polymers

Continuous Confinement Fluidics: Getting Lots of Molecules into Small Spaces with High Fidelity
Mohammed Jalal Ahamed, Sara Mahshid, Daniel J Berard, François Michaud, Rob Sladek, Walter W Reisner, Sabrina R Leslie.
Macromolecules

Nonequilibrium Dynamics of Nanochannel Confined DNA
Ahmed Khorshid, Susan Amin, Zhiyue Zhang, Takahiro Sakaue, Walter W Reisner.
Macromolecules

Transition state theory demonstrated at the micron scale with out-of-equilibrium transport in a confined environment
Christian L Vestergaard, Morten Bo Mikkelsen, Walter Reisner, Anders Kristensen, Henrik Flyvbjerg.
Nature communications

Fabrication and characterization of nanopore-interfaced nanochannel devices
Yuning Zhang and Walter Reisner.
Nanotechnology

Measuring the Confinement Free Energy and Effective Width of Single Polymer Chains via Single-Molecule Tetris
Alexander R. Klotz, Lyndon Duong, Mikhail Mamaev, Hendrick W. de Haan, Jeff Z.Y. Chen, and Walter Reisner.
Macromolecules

Experimental Evidence of Weak Excluded Volume Effects for Nanochannel Confined DNA
Damini Gupta, Jeremy J. Miller, Abhiram Muralidhar, Sara Mahshid, Walter Reisner, and Kevin D. Dorfman.
Macro Letters

Correlated Fluctuations of DNA between Nanofluidic Entropic Traps
Alexander R. Klotz, Mikhail Mamaev, Lyndon Duong, Hendrick W. de Haan, and Walter Reisner.
Macromolecules

Dynamic Imaging of Au-nanoparticles via Scanning Electron Microscopy in a Graphene Wet Cell
Wayne Yang, Yuning Zhang, Michael Hilke, and Walter Reisner.
arXiv.org, accepted to Nanotechnology

Development of a Platform for Single Cell Genomics Using Convex Lens-Induced Confinement
Sara Mahshid , Mohammed Jalal Ahamed , Daniel Berard , Susan Amin , Robert Sladek , Sabrina Leslie and Walter Reisner.
Lab on a Chip

Dynamic compression of single nanochannel confined DNA via a nanodozer assay
Ahmed Khorshid, Philip Zimny, David T�treault-La Roche, Geremia Massarelli, Takahiro Sakaue, and Walter Reisner.
Physical Review Letters, 113, 268104

Mixed confinement regimes during equilibrium confinement spectroscopy of DNA
Damini Gupta, Julian Sheats, Abhiram Muralidhar, Jeremy J. Miller, Derek E. Huang, Sara Mahshid, Kevin D. Dorfman and Walter Reisner.
J. Chem. Phys. 140, 214901

Convex Lens-Induced Nanoscale Templating
Daniel J. Berard, Fran�ois Michaud, Sara Mahshid,b, Mohammed Jalal Ahamed, Christopher M. J. McFaul, Jason S. Leith, Pierre B�rub�, Rob Sladek, Walter Reisner and Sabrina R. Leslie.
PNAS, August 2014

Diffusion resonance of Nanoconfined Polymers
A. Klotz, H. Brandao, and W. Reisner.
Macromolecules 45, 5 (2012)

Denaturation Mapping of Saccharomyces cerevisiae
R. Welch et al.
Lab on a Chip 12, 3314-3321 (2012)

DNA Confinement in Nanochannels: Physics and Biological Applications
W. Reisner et al.
Reports on Progress in Physics, 75, 10 (2012)

DNA Barcoding via Counterstaining with AT/GC Sensitive Ligands in Injection-Molded All-Polymer Nanochannel Devices
P. Friis Ostergaard et al.
Analyst (2012)

2011
Collapse of DNA in ac Electric Fields
C. Zhou, W. Reisner, et al.
Physical Review Letters 106, 84 (2011)

Pressure-Driven DNA in Nanogroove Arrays: Complex Dynamics Leads to Length- and Topology-Dependent Separation
M. Mikkelsen, W. Reisner, et al.
Nano Letters 11, 4 (2011)

Single-molecule denaturation mapping of DNA in nanofluidic channels
W. Reisner et al.,
PNAS107, 30 (2010)

Directed Self-Organization of Single DNA Molecules in a Nanoslit via Embedded Nanopit Arrays.
W. Reisner et al.
PNAS 106, 79-84 (2009)

Confinement Spectroscopy: Probing Single DNA Molecules with Tapered Nanochannels.
F. Persson, P. Utko, W. Reisner et al.
Nano Letters 9, 1382-1385 (2009)

Pressure-Driven DNA Transport across an Artifical Nanotopography.
JT Del Bonis-O'Donnell, W. Reisner, Derek Stein.
New Journal of Physics 11,075032 (2009)